Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TONSLTonsoku like, DNA repair protein. (1417 aa)    
Predicted Functional Partners:
MMS22L
MMS22 like, DNA repair protein.
    
 
 0.982
ASF1A
Anti-silencing function 1A histone chaperone.
   
 
 0.968
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 
 0.964
MCM2
DNA helicase; Belongs to the MCM family.
   
 
 0.963
ASF1B
Anti-silencing function 1B histone chaperone.
   
 
 0.961
MCM6
DNA helicase; Belongs to the MCM family.
   
 
 0.921
EMSY
EMSY transcriptional repressor, BRCA2 interacting.
   
  
 0.840
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
    
 
 0.830
APTX
Aprataxin.
   
  
 0.828
BRCA1
BRCA1 DNA repair associated.
    
 0.811
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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