TONSL protein (Latimeria chalumnae) - STRING interaction network

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Score

TONSL

Tonsoku like, DNA repair protein. (1417 aa)

Predicted Functional Partners:

MCM2

0.900

MMS22L

0.828

APTX

0.819

EMSY

0.815

LOC102346166

0.711

RPS27A

0.711

RNF8

0.709

ASF1B

0.675

LOC102350907

0.667

KXD1

0.667

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APTX	EMSY	ENSLACP00000003789	ENSLACP00000007249	Aprataxin.	EMSY transcriptional repressor, BRCA2 interacting.	0.804
APTX	RNF8	ENSLACP00000003789	ENSLACP00000007009	Aprataxin.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.590
APTX	TONSL	ENSLACP00000003789	ENSLACP00000004904	Aprataxin.	Tonsoku like, DNA repair protein.	0.819
ASF1B	MCM2	ENSLACP00000007270	ENSLACP00000012499	Anti-silencing function 1B histone chaperone.	DNA helicase; Belongs to the MCM family.	0.959
ASF1B	MMS22L	ENSLACP00000007270	ENSLACP00000006382	Anti-silencing function 1B histone chaperone.	MMS22 like, DNA repair protein.	0.646
ASF1B	TONSL	ENSLACP00000007270	ENSLACP00000004904	Anti-silencing function 1B histone chaperone.	Tonsoku like, DNA repair protein.	0.675
EMSY	APTX	ENSLACP00000007249	ENSLACP00000003789	EMSY transcriptional repressor, BRCA2 interacting.	Aprataxin.	0.804
EMSY	RNF8	ENSLACP00000007249	ENSLACP00000007009	EMSY transcriptional repressor, BRCA2 interacting.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.677
EMSY	TONSL	ENSLACP00000007249	ENSLACP00000004904	EMSY transcriptional repressor, BRCA2 interacting.	Tonsoku like, DNA repair protein.	0.815
KXD1	LOC102346166	ENSLACP00000009213	ENSLACP00000003410	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.977
KXD1	RNF8	ENSLACP00000009213	ENSLACP00000007009	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.817
KXD1	RPS27A	ENSLACP00000009213	ENSLACP00000008678	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.999
KXD1	TONSL	ENSLACP00000009213	ENSLACP00000004904	Ubiquitin-like domain-containing protein.	Tonsoku like, DNA repair protein.	0.667
LOC102346166	KXD1	ENSLACP00000003410	ENSLACP00000009213	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.977
LOC102346166	LOC102350907	ENSLACP00000003410	ENSLACP00000003879	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.977
LOC102346166	MCM2	ENSLACP00000003410	ENSLACP00000012499	Ubiquitin-like domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.549
LOC102346166	RNF8	ENSLACP00000003410	ENSLACP00000007009	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.857
LOC102346166	TONSL	ENSLACP00000003410	ENSLACP00000004904	Ubiquitin-like domain-containing protein.	Tonsoku like, DNA repair protein.	0.711
LOC102350907	LOC102346166	ENSLACP00000003879	ENSLACP00000003410	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ubiquitin-like domain-containing protein.	0.977
LOC102350907	RNF8	ENSLACP00000003879	ENSLACP00000007009	Ubiquitin A-52 residue ribosomal protein fusion product 1.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.817