Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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[Homology]
Score
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (478 aa)    
Predicted Functional Partners:
PDPK1
3-phosphoinositide dependent protein kinase 1.
   
0.991
TSC2
TSC complex subunit 2.
    
 0.988
MDM2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
    
 0.988
TSC1
TSC complex subunit 1.
    
 0.987
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
0.986
AKT1S1
AKT1 substrate 1.
   
 0.985
CDKN1A
Cyclin dependent kinase inhibitor 1A.
    
 0.978
H3B8U3_LATCH
Serine/threonine-protein kinase TOR.
    
 0.978
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.976
ILK
Integrin linked kinase.
   
 0.975
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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