Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EPS8Epidermal growth factor receptor pathway substrate 8. (774 aa)    
Predicted Functional Partners:
ABI1
Abl interactor 1.
   
 
 0.892
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 
 0.885
BAIAP2
BAI1 associated protein 2.
    
 
 0.859
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
   
 0.806
ESPNL
Espin like.
     
 0.787
TWF1
Twinfilin actin binding protein 1.
     
 0.748
MPP1
Membrane palmitoylated protein 1; Belongs to the MAGUK family.
   
 0.725
ESPN
Espin.
     
 0.718
H3A478_LATCH
PDZ domain-containing protein.
     
 0.653
H3AIG1_LATCH
Uncharacterized protein.
     
 0.653
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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