Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF20E3 ubiquitin protein ligase. (1004 aa)    
Predicted Functional Partners:
WAC
WW domain containing adaptor with coiled-coil.
   
 0.926
CDC73
Cell division cycle 73.
   
 0.885
PAF1
PAF1 homolog, Paf1/RNA polymerase II complex component.
    
 0.882
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 0.878
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.865
RPS27A
Ribosomal protein S27a.
   
 0.846
UBE2A
Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.834
UBE2B
Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.834
LOC102347893
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.834
CTR9
CTR9 homolog, Paf1/RNA polymerase II complex component.
   
 0.813
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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