GGCX protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

GGCX

Gamma-glutamyl carboxylase. (684 aa)

Predicted Functional Partners:

LOC102357927

0.992

F2

0.987

LOC102358409

0.963

PROS1

0.963

NQO1

0.948

FAM136A

0.948

VKORC1L1

0.935

PRRG1

0.927

GMCL1

0.898

SLC35E4

0.889

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F2	GGCX	ENSLACP00000021404	ENSLACP00000005039	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Gamma-glutamyl carboxylase.	0.987
F2	LOC102357927	ENSLACP00000021404	ENSLACP00000010163	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	VKc domain-containing protein.	0.642
F2	LOC102358409	ENSLACP00000021404	ENSLACP00000009670	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.989
F2	PROS1	ENSLACP00000021404	ENSLACP00000016613	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein S.	0.469
FAM136A	GGCX	ENSLACP00000020379	ENSLACP00000005039	Family with sequence similarity 136 member A.	Gamma-glutamyl carboxylase.	0.948
FAM136A	GMCL1	ENSLACP00000020379	ENSLACP00000020535	Family with sequence similarity 136 member A.	Germ cell-less, spermatogenesis associated.	0.857
FAM136A	SLC35E4	ENSLACP00000020379	ENSLACP00000018666	Family with sequence similarity 136 member A.	Solute carrier family 35 member E4.	0.884
GGCX	F2	ENSLACP00000005039	ENSLACP00000021404	Gamma-glutamyl carboxylase.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.987
GGCX	FAM136A	ENSLACP00000005039	ENSLACP00000020379	Gamma-glutamyl carboxylase.	Family with sequence similarity 136 member A.	0.948
GGCX	GMCL1	ENSLACP00000005039	ENSLACP00000020535	Gamma-glutamyl carboxylase.	Germ cell-less, spermatogenesis associated.	0.898
GGCX	LOC102357927	ENSLACP00000005039	ENSLACP00000010163	Gamma-glutamyl carboxylase.	VKc domain-containing protein.	0.992
GGCX	LOC102358409	ENSLACP00000005039	ENSLACP00000009670	Gamma-glutamyl carboxylase.	Uncharacterized protein.	0.963
GGCX	NQO1	ENSLACP00000005039	ENSLACP00000009170	Gamma-glutamyl carboxylase.	NAD(P)H quinone dehydrogenase 1.	0.948
GGCX	PROS1	ENSLACP00000005039	ENSLACP00000016613	Gamma-glutamyl carboxylase.	Protein S.	0.963
GGCX	PRRG1	ENSLACP00000005039	ENSLACP00000012163	Gamma-glutamyl carboxylase.	Gla domain-containing protein.	0.927
GGCX	SLC35E4	ENSLACP00000005039	ENSLACP00000018666	Gamma-glutamyl carboxylase.	Solute carrier family 35 member E4.	0.889
GGCX	VKORC1L1	ENSLACP00000005039	ENSLACP00000021487	Gamma-glutamyl carboxylase.	Vitamin K epoxide reductase complex subunit 1 like 1.	0.935
GMCL1	FAM136A	ENSLACP00000020535	ENSLACP00000020379	Germ cell-less, spermatogenesis associated.	Family with sequence similarity 136 member A.	0.857
GMCL1	GGCX	ENSLACP00000020535	ENSLACP00000005039	Germ cell-less, spermatogenesis associated.	Gamma-glutamyl carboxylase.	0.898
GMCL1	SLC35E4	ENSLACP00000020535	ENSLACP00000018666	Germ cell-less, spermatogenesis associated.	Solute carrier family 35 member E4.	0.822