Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1549 aa)    
Predicted Functional Partners:
RPS27A
Ribosomal protein S27a.
    
  0.763
ARRDC1
Arrestin domain containing 1.
    
 
 0.751
TOX4
TOX high mobility group box family member 4.
    
 0.717
CHD8
Chromodomain helicase DNA binding protein 8.
   
 
 0.715
STARD3NL
STARD3 N-terminal like.
      
 0.709
SALL2
Uncharacterized protein.
      
 0.709
GPM6A
Glycoprotein M6A.
      
 0.701
GJA1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
    
 0.682
PDIA2
Protein disulfide-isomerase.
    
 
 0.676
LOC102354416
Uncharacterized protein.
    
 0.676
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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