GRK7 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

GRK7

G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (536 aa)

Predicted Functional Partners:

RHO

0.992

LOC102347432

0.991

H2ZZF8_LATCH

0.985

LOC102362932

0.930

GRK1

0.930

ARRB2

0.899

ARRB1

0.899

SAG

0.830

LOC102361323

0.813

LOC102365300

0.804

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSLACP00000003241	ENSLACP00000002241	Arrestin beta 1.	Arrestin, beta 2a.	0.901
ARRB1	GRK1	ENSLACP00000003241	ENSLACP00000013959	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.866
ARRB1	GRK7	ENSLACP00000003241	ENSLACP00000005098	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.899
ARRB1	H2ZZF8_LATCH	ENSLACP00000003241	ENSLACP00000002779	Arrestin beta 1.	Recoverin 3.	0.520
ARRB1	LOC102347432	ENSLACP00000003241	ENSLACP00000018849	Arrestin beta 1.	Rhodopsin.	0.856
ARRB1	LOC102362932	ENSLACP00000003241	ENSLACP00000012812	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.866
ARRB1	LOC102365300	ENSLACP00000003241	ENSLACP00000002000	Arrestin beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.438
ARRB1	RHO	ENSLACP00000003241	ENSLACP00000014823	Arrestin beta 1.	Rhodopsin.	0.856
ARRB2	ARRB1	ENSLACP00000002241	ENSLACP00000003241	Arrestin, beta 2a.	Arrestin beta 1.	0.901
ARRB2	GRK1	ENSLACP00000002241	ENSLACP00000013959	Arrestin, beta 2a.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.866
ARRB2	GRK7	ENSLACP00000002241	ENSLACP00000005098	Arrestin, beta 2a.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.899
ARRB2	H2ZZF8_LATCH	ENSLACP00000002241	ENSLACP00000002779	Arrestin, beta 2a.	Recoverin 3.	0.520
ARRB2	LOC102347432	ENSLACP00000002241	ENSLACP00000018849	Arrestin, beta 2a.	Rhodopsin.	0.856
ARRB2	LOC102362932	ENSLACP00000002241	ENSLACP00000012812	Arrestin, beta 2a.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.866
ARRB2	LOC102365300	ENSLACP00000002241	ENSLACP00000002000	Arrestin, beta 2a.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.438
ARRB2	RHO	ENSLACP00000002241	ENSLACP00000014823	Arrestin, beta 2a.	Rhodopsin.	0.856
GRK1	ARRB1	ENSLACP00000013959	ENSLACP00000003241	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Arrestin beta 1.	0.866
GRK1	ARRB2	ENSLACP00000013959	ENSLACP00000002241	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Arrestin, beta 2a.	0.866
GRK1	GRK7	ENSLACP00000013959	ENSLACP00000005098	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.930
GRK1	H2ZZF8_LATCH	ENSLACP00000013959	ENSLACP00000002779	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Recoverin 3.	0.984