Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PLK5Serine/threonine-protein kinase PLK. (627 aa)    
Predicted Functional Partners:
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 0.946
KIF23
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 0.931
CDC20
Cell division cycle 20.
   
 0.918
CDC20B
Cell division cycle 20B.
   
 0.918
ESPL1
Extra spindle pole bodies like 1, separase.
   
 0.906
WEE1
WEE1 G2 checkpoint kinase.
   
 0.900
FZR1
Fizzy and cell division cycle 20 related 1.
   
 0.896
CCNB2
Cyclin B2; Belongs to the cyclin family.
   
 0.888
MAD2L1
Mitotic arrest deficient 2 like 1.
   
 0.882
SMC3
Structural maintenance of chromosomes protein.
   
 0.880
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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