Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
RAB5ARAB5A, member RAS oncogene family. (230 aa)    
Predicted Functional Partners:
LOC102354752
VPS9 domain-containing protein.
   
 0.990
RABGEF1
RAB guanine nucleotide exchange factor (GEF) 1.
   
 0.990
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 0.973
VPS18
VPS18 core subunit of CORVET and HOPS complexes.
   
 0.965
VPS11
Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.
    
 0.961
EEA1
Early endosome antigen 1.
    
 0.952
TGFBRAP1
Transforming growth factor beta receptor associated protein 1.
    
 0.951
RBSN
Rabenosyn, RAB effector.
    
 0.934
VPS8
VPS8 subunit of CORVET complex.
    
 0.925
VPS45
Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.
    
 0.869
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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