Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SERPINE2Serpin family E member 2; Belongs to the serpin family. (403 aa)    
Predicted Functional Partners:
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
    
 0.983
PLAU
Uncharacterized protein.
   
 0.964
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
   
 0.945
SNX4
Sorting nexin 4.
      
 0.795
HABP2
Hyaluronan binding protein 2.
   
 0.731
H3A2J8_LATCH
Uncharacterized protein.
   
 0.731
PLG
Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.729
F8
Coagulation factor VIII; Belongs to the multicopper oxidase family.
    
 0.677
SNX1
PX domain-containing protein.
      
 0.672
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
     
  0.671
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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