SERPINE2 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SERPINE2

Serpin family E member 2; Belongs to the serpin family. (403 aa)

Predicted Functional Partners:

F2

0.981

PLAT

0.886

PLAU

0.851

VTN

0.795

F5

0.743

HABP2

0.699

H3A2J8_LATCH

0.699

F8

0.681

SERPINE1

0.666

LOC102363384

0.612

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F2	F5	ENSLACP00000021404	ENSLACP00000018437	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor V; Belongs to the multicopper oxidase family.	0.979
F2	F8	ENSLACP00000021404	ENSLACP00000016108	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VIII; Belongs to the multicopper oxidase family.	0.932
F2	HABP2	ENSLACP00000021404	ENSLACP00000002018	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Hyaluronan binding protein 2.	0.437
F2	LOC102363384	ENSLACP00000021404	ENSLACP00000022159	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.862
F2	PLAT	ENSLACP00000021404	ENSLACP00000015011	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Plasminogen activator; Belongs to the peptidase S1 family.	0.411
F2	SERPINE1	ENSLACP00000021404	ENSLACP00000006192	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family E member 1; Belongs to the serpin family.	0.507
F2	SERPINE2	ENSLACP00000021404	ENSLACP00000005293	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family E member 2; Belongs to the serpin family.	0.981
F2	VTN	ENSLACP00000021404	ENSLACP00000021946	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Vitronectin b.	0.702
F5	F2	ENSLACP00000018437	ENSLACP00000021404	Coagulation factor V; Belongs to the multicopper oxidase family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.979
F5	F8	ENSLACP00000018437	ENSLACP00000016108	Coagulation factor V; Belongs to the multicopper oxidase family.	Coagulation factor VIII; Belongs to the multicopper oxidase family.	0.718
F5	LOC102363384	ENSLACP00000018437	ENSLACP00000022159	Coagulation factor V; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.641
F5	SERPINE2	ENSLACP00000018437	ENSLACP00000005293	Coagulation factor V; Belongs to the multicopper oxidase family.	Serpin family E member 2; Belongs to the serpin family.	0.743
F8	F2	ENSLACP00000016108	ENSLACP00000021404	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.932
F8	F5	ENSLACP00000016108	ENSLACP00000018437	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Coagulation factor V; Belongs to the multicopper oxidase family.	0.718
F8	LOC102363384	ENSLACP00000016108	ENSLACP00000022159	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.525
F8	PLAT	ENSLACP00000016108	ENSLACP00000015011	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Plasminogen activator; Belongs to the peptidase S1 family.	0.441
F8	SERPINE1	ENSLACP00000016108	ENSLACP00000006192	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Serpin family E member 1; Belongs to the serpin family.	0.423
F8	SERPINE2	ENSLACP00000016108	ENSLACP00000005293	Coagulation factor VIII; Belongs to the multicopper oxidase family.	Serpin family E member 2; Belongs to the serpin family.	0.681
H3A2J8_LATCH	LOC102363384	ENSLACP00000003869	ENSLACP00000022159	Uncharacterized protein.	Uncharacterized protein.	0.436
H3A2J8_LATCH	SERPINE1	ENSLACP00000003869	ENSLACP00000006192	Uncharacterized protein.	Serpin family E member 1; Belongs to the serpin family.	0.433