STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CUL4BCullin 4B; Belongs to the cullin family. (845 aa)    
Predicted Functional Partners:
DDB1
Damage specific DNA binding protein 1.
   
 0.987
RBX1
Ring-box 1.
    
 0.963
DTL
Denticleless E3 ubiquitin protein ligase homolog.
    
 0.953
ERCC8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit.
    
 0.941
CUL4A
Cullin 4A; Belongs to the cullin family.
  
  
0.939
COPS5
COP9 signalosome subunit 5.
    
 0.914
DCAF1
DDB1 and CUL4 associated factor 1.
   
 
 0.908
COPS4
COP9 signalosome subunit 4.
    
 0.905
NEDD8
NEDD8 ubiquitin like modifier.
    
 0.900
DDA1
DET1 and DDB1 associated 1.
    
 0.897
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.