Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MEGF8Multiple EGF like domains 8. (2553 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
     
  0.900
MGRN1
Mahogunin ring finger 1.
   
 
 0.841
MOSMO
Modulator of smoothened.
    
 
 0.634
BCL3
BCL3 transcription coactivator.
    
 
 0.622
TBC1D31
TBC1 domain family member 31.
    
 0.618
ANKRD46
Ankyrin repeat domain 46.
    
   0.605
BCS1L
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family.
      
 0.589
SLX4IP
Uncharacterized protein.
      
 0.586
LOC102345521
Cathepsin F; Belongs to the peptidase C1 family.
      
 0.583
RNF157
Ring finger protein 157.
   
 
 0.573
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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