Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (428 aa)    
Predicted Functional Partners:
PANX2
Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.
     
0.952
P2RX6
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
     
 0.870
CASP7
Caspase 7; Belongs to the peptidase C14A family.
    
 
 0.815
GJB1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.771
P2RX1
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
     
 0.751
GRPR
Gastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.714
ENTPD3
Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.
      
 0.708
LOC102363742
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 
 0.707
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 
 0.691
LOC102367521
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 
 0.691
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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