Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NUAK1NUAK family kinase 1. (670 aa)    
Predicted Functional Partners:
FBXW11
F-box and WD repeat domain containing 11.
    
   0.902
STK11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
    
 0.892
LOC102351883
Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family.
    
 
 0.854
H3A8H2_LATCH
Uncharacterized protein.
    
   0.780
RIC8B
RIC8 guanine nucleotide exchange factor B.
      
 0.720
BTBD11
BTB domain containing 11.
      
 0.703
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.680
UHRF1BP1
UHRF1 binding protein 1.
      
 0.677
LYPD6B
LY6/PLAUR domain containing 6B.
      
 0.671
LMOD1
Leiomodin 1.
   
  
 0.656
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.