STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUAK1NUAK family kinase 1. (670 aa)    
Predicted Functional Partners:
STK11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
  
 
0.886
BTBD11
BTB domain containing 11.
      
 0.688
STAB2
Stabilin 2.
      
 0.654
RIC8B
RIC8 guanine nucleotide exchange factor B.
      
 0.617
PPFIBP1
PPFIA binding protein 1.
      
 0.605
TMEM150B
Transmembrane protein 150B.
      
 0.572
LOC102351883
Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family.
    
 
 0.517
SESN1
Sestrin 1.
      
 0.507
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.505
HSPA4
Heat shock protein family A (Hsp70) member 4.
      
 0.503
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.