Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (538 aa)    
Predicted Functional Partners:
KPNB1
Karyopherin subunit beta 1.
   
 0.999
CSE1L
Chromosome segregation 1 like.
   
 0.985
NUP50
Nucleoporin 50.
   
 
 0.973
KPNA3
Importin subunit alpha; Belongs to the importin alpha family.
  
0.962
KPNA4
Importin subunit alpha; Belongs to the importin alpha family.
  
0.958
RNMT
mRNA cap guanine-N7 methyltransferase.
   
   0.928
RAG1
V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]
    
 
 0.923
KPNA6
Importin subunit alpha; Belongs to the importin alpha family.
   
  0.915
KPNA5
Importin subunit alpha; Belongs to the importin alpha family.
   
  0.915
NFKB1
Nuclear factor kappa B subunit 1.
    
  0.910
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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