Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)    
Predicted Functional Partners:
CCND1
Cyclin D1; Belongs to the cyclin family.
   
 0.997
RB1
Uncharacterized protein.
   
 0.992
LOC102356560
ANK_REP_REGION domain-containing protein.
    
 0.989
CDKN2C
Cyclin dependent kinase inhibitor 2C.
   
 0.988
LOC102345953
Cyclin D3; Belongs to the cyclin family.
   
 0.988
CCND2
Cyclin D2, b; Belongs to the cyclin family.
   
 0.988
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.987
RBL2
RB transcriptional corepressor like 2.
   
 0.972
RBL1
RB transcriptional corepressor like 1.
   
 0.972
CDKN1A
Cyclin dependent kinase inhibitor 1A.
   
 0.968
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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