Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H3A8K8_LATCHSema domain-containing protein. (2101 aa)    
Predicted Functional Partners:
MET
MET proto-oncogene, receptor tyrosine kinase.
    
0.911
RND1
Rho family GTPase 1.
    
 0.854
SEMA4D
Semaphorin 4D; Belongs to the semaphorin family.
    
 0.837
LOC102366200
Uncharacterized protein; Belongs to the semaphorin family.
    
 0.837
RND3
Rho family GTPase 3.
    
 0.825
H3AY29_LATCH
Uncharacterized protein.
    
 0.790
RND2
Rho family GTPase 2.
    
 0.767
NRP1
Neuropilin; Belongs to the neuropilin family.
   
 0.680
PTPN23
Protein tyrosine phosphatase non-receptor type 23.
   
 0.665
ARHGEF11
Rho guanine nucleotide exchange factor 11.
    
 0.654
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (34%) [HD]