SPCS2 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SPCS2

Signal peptidase complex subunit 2. (173 aa)

Predicted Functional Partners:

SPCS1

0.999

SPCS3

0.993

SEC11C

0.955

SEC11A

0.955

GRP

0.906

SEC63

0.887

HSPA5

0.831

DDOST

0.827

SEC62

0.822

CPE

0.810

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPE	SPCS2	ENSLACP00000022178	ENSLACP00000006006	Carboxypeptidase E.	Signal peptidase complex subunit 2.	0.810
DDOST	HSPA5	ENSLACP00000006059	ENSLACP00000020775	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.688
DDOST	SEC63	ENSLACP00000006059	ENSLACP00000016449	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]	SEC63 homolog, protein translocation regulator.	0.849
DDOST	SPCS1	ENSLACP00000006059	ENSLACP00000022972	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]	Signal peptidase complex subunit 1.	0.615
DDOST	SPCS2	ENSLACP00000006059	ENSLACP00000006006	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]	Signal peptidase complex subunit 2.	0.827
DDOST	SPCS3	ENSLACP00000006059	ENSLACP00000022719	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]	Signal peptidase complex subunit 3.	0.679
GRP	SEC63	ENSLACP00000023192	ENSLACP00000016449	Gastrin-releasing peptide.	SEC63 homolog, protein translocation regulator.	0.509
GRP	SPCS1	ENSLACP00000023192	ENSLACP00000022972	Gastrin-releasing peptide.	Signal peptidase complex subunit 1.	0.943
GRP	SPCS2	ENSLACP00000023192	ENSLACP00000006006	Gastrin-releasing peptide.	Signal peptidase complex subunit 2.	0.906
GRP	SPCS3	ENSLACP00000023192	ENSLACP00000022719	Gastrin-releasing peptide.	Signal peptidase complex subunit 3.	0.942
HSPA5	DDOST	ENSLACP00000020775	ENSLACP00000006059	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]	0.688
HSPA5	SEC62	ENSLACP00000020775	ENSLACP00000017650	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	SEC62 homolog, preprotein translocation factor.	0.609
HSPA5	SEC63	ENSLACP00000020775	ENSLACP00000016449	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	SEC63 homolog, protein translocation regulator.	0.969
HSPA5	SPCS1	ENSLACP00000020775	ENSLACP00000022972	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Signal peptidase complex subunit 1.	0.620
HSPA5	SPCS2	ENSLACP00000020775	ENSLACP00000006006	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Signal peptidase complex subunit 2.	0.831
HSPA5	SPCS3	ENSLACP00000020775	ENSLACP00000022719	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Signal peptidase complex subunit 3.	0.575
SEC11A	SEC11C	ENSLACP00000017376	ENSLACP00000012484	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase complex catalytic subunit SEC11.	0.901
SEC11A	SEC63	ENSLACP00000017376	ENSLACP00000016449	Signal peptidase complex catalytic subunit SEC11.	SEC63 homolog, protein translocation regulator.	0.509
SEC11A	SPCS1	ENSLACP00000017376	ENSLACP00000022972	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase complex subunit 1.	0.972
SEC11A	SPCS2	ENSLACP00000017376	ENSLACP00000006006	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase complex subunit 2.	0.955