GRB14 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GRB14

Growth factor receptor bound protein 14. (453 aa)

Predicted Functional Partners:

LOC102348007

0.611

PIK3R1

0.611

GRB2

0.606

RET

0.589

H3ACE0_LATCH

0.568

WDR90

0.553

TEK

0.553

GRAP2

0.552

H3AZT3_LATCH

0.552

PDGFRB

0.523

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRAP2	GRB14	ENSLACP00000012066	ENSLACP00000006262	GRB2 related adaptor protein 2.	Growth factor receptor bound protein 14.	0.552
GRAP2	GRB2	ENSLACP00000012066	ENSLACP00000000662	GRB2 related adaptor protein 2.	Growth factor receptor bound protein 2.	0.895
GRAP2	H3ACE0_LATCH	ENSLACP00000012066	ENSLACP00000007311	GRB2 related adaptor protein 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.452
GRAP2	LOC102348007	ENSLACP00000012066	ENSLACP00000008684	GRB2 related adaptor protein 2.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.674
GRAP2	PIK3R1	ENSLACP00000012066	ENSLACP00000015476	GRB2 related adaptor protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.674
GRAP2	RET	ENSLACP00000012066	ENSLACP00000004888	GRB2 related adaptor protein 2.	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.403
GRB14	GRAP2	ENSLACP00000006262	ENSLACP00000012066	Growth factor receptor bound protein 14.	GRB2 related adaptor protein 2.	0.552
GRB14	GRB2	ENSLACP00000006262	ENSLACP00000000662	Growth factor receptor bound protein 14.	Growth factor receptor bound protein 2.	0.606
GRB14	H3ACE0_LATCH	ENSLACP00000006262	ENSLACP00000007311	Growth factor receptor bound protein 14.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.568
GRB14	H3AZT3_LATCH	ENSLACP00000006262	ENSLACP00000015154	Growth factor receptor bound protein 14.	GRB2 related adaptor protein b.	0.552
GRB14	LOC102348007	ENSLACP00000006262	ENSLACP00000008684	Growth factor receptor bound protein 14.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.611
GRB14	PDGFRB	ENSLACP00000006262	ENSLACP00000016550	Growth factor receptor bound protein 14.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.523
GRB14	PIK3R1	ENSLACP00000006262	ENSLACP00000015476	Growth factor receptor bound protein 14.	Phosphoinositide-3-kinase regulatory subunit 1.	0.611
GRB14	RET	ENSLACP00000006262	ENSLACP00000004888	Growth factor receptor bound protein 14.	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.589
GRB14	TEK	ENSLACP00000006262	ENSLACP00000011084	Growth factor receptor bound protein 14.	TEK receptor tyrosine kinase.	0.553
GRB14	WDR90	ENSLACP00000006262	ENSLACP00000002441	Growth factor receptor bound protein 14.	WD repeat domain 90.	0.553
GRB2	GRAP2	ENSLACP00000000662	ENSLACP00000012066	Growth factor receptor bound protein 2.	GRB2 related adaptor protein 2.	0.895
GRB2	GRB14	ENSLACP00000000662	ENSLACP00000006262	Growth factor receptor bound protein 2.	Growth factor receptor bound protein 14.	0.606
GRB2	H3ACE0_LATCH	ENSLACP00000000662	ENSLACP00000007311	Growth factor receptor bound protein 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.701
GRB2	H3AZT3_LATCH	ENSLACP00000000662	ENSLACP00000015154	Growth factor receptor bound protein 2.	GRB2 related adaptor protein b.	0.547