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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PITX2Homeobox protein. (314 aa)    
Predicted Functional Partners:
PAX9
Paired box 9.
   
  
 0.569
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
      
 0.550
BMP4
Bone morphogenetic protein 4.
      
 0.548
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.537
ABLIM1
Actin binding LIM protein 1.
      
 0.495
OSR2
Odd-skipped related transciption factor 2.
    
 
 0.484
LEF1
Lymphoid enhancer binding factor 1.
    
 
 0.453
BMP6
Bone morphogenetic protein 6.
   
  
 0.450
LOC102357009
Southpaw.
      
 0.432
ISL1
ISL LIM homeobox 1.
    
 
 0.432
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.