Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PITX2Homeobox protein. (314 aa)    
Predicted Functional Partners:
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
      
 0.651
LHX3
LIM homeobox 3.
   
  
 0.594
EDAR
Ectodysplasin A receptor.
      
 0.567
LEF1
Lymphoid enhancer binding factor 1.
    
 
 0.567
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.559
CTNNB1
Catenin beta 1.
    
 
 0.557
BMP4
Bone morphogenetic protein 4.
      
 0.557
PAX9
Paired box 9.
   
  
 0.544
LHX4
LIM homeobox 4.
   
  
 0.542
LRTM2
Leucine rich repeats and transmembrane domains 2.
      
 0.538
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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