Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
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LOC102355250Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa)    
Predicted Functional Partners:
SLX4
BTB domain-containing protein.
   
 0.999
H3AZT0_LATCH
Uncharacterized protein.
   
 0.986
MUS81
Uncharacterized protein.
   
 0.984
EME1
Essential meiotic structure-specific endonuclease 1.
    
 0.975
BLM
BLM RecQ like helicase.
    
 0.961
H2ZWI5_LATCH
Uncharacterized protein.
    
 0.958
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
   
 0.946
NARS1
Asparaginyl-tRNA synthetase.
   
 0.938
FANCM
FA complementation group M.
   
 0.932
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.928
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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