GNA12 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

GNA12

G protein subunit alpha 12. (382 aa)

Predicted Functional Partners:

GNA13

0.870

GNB3

0.825

GNB4

0.825

GNB1

0.825

ARHGEF11

0.810

ARHGEF1

0.810

ARHGEF12

0.810

GNG2

0.784

MAPK13

0.778

H3AES2_LATCH

0.778

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF1	GNA12	ENSLACP00000008386	ENSLACP00000006367	Rho guanine nucleotide exchange factor 1.	G protein subunit alpha 12.	0.810
ARHGEF1	GNA13	ENSLACP00000008386	ENSLACP00000019021	Rho guanine nucleotide exchange factor 1.	G protein subunit alpha 13.	0.834
ARHGEF11	GNA12	ENSLACP00000002825	ENSLACP00000006367	Rho guanine nucleotide exchange factor 11.	G protein subunit alpha 12.	0.810
ARHGEF11	GNA13	ENSLACP00000002825	ENSLACP00000019021	Rho guanine nucleotide exchange factor 11.	G protein subunit alpha 13.	0.834
ARHGEF12	GNA12	ENSLACP00000010515	ENSLACP00000006367	Rho guanine nucleotide exchange factor 12.	G protein subunit alpha 12.	0.810
ARHGEF12	GNA13	ENSLACP00000010515	ENSLACP00000019021	Rho guanine nucleotide exchange factor 12.	G protein subunit alpha 13.	0.834
GNA12	ARHGEF1	ENSLACP00000006367	ENSLACP00000008386	G protein subunit alpha 12.	Rho guanine nucleotide exchange factor 1.	0.810
GNA12	ARHGEF11	ENSLACP00000006367	ENSLACP00000002825	G protein subunit alpha 12.	Rho guanine nucleotide exchange factor 11.	0.810
GNA12	ARHGEF12	ENSLACP00000006367	ENSLACP00000010515	G protein subunit alpha 12.	Rho guanine nucleotide exchange factor 12.	0.810
GNA12	GNA13	ENSLACP00000006367	ENSLACP00000019021	G protein subunit alpha 12.	G protein subunit alpha 13.	0.870
GNA12	GNB1	ENSLACP00000006367	ENSLACP00000021768	G protein subunit alpha 12.	G protein subunit beta 1.	0.825
GNA12	GNB3	ENSLACP00000006367	ENSLACP00000008451	G protein subunit alpha 12.	G protein subunit beta 3.	0.825
GNA12	GNB4	ENSLACP00000006367	ENSLACP00000016952	G protein subunit alpha 12.	G protein subunit beta 4.	0.825
GNA12	GNG2	ENSLACP00000006367	ENSLACP00000018370	G protein subunit alpha 12.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.784
GNA12	H3AES2_LATCH	ENSLACP00000006367	ENSLACP00000008143	G protein subunit alpha 12.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.778
GNA12	MAPK13	ENSLACP00000006367	ENSLACP00000000782	G protein subunit alpha 12.	Mitogen-activated protein kinase.	0.778
GNA13	ARHGEF1	ENSLACP00000019021	ENSLACP00000008386	G protein subunit alpha 13.	Rho guanine nucleotide exchange factor 1.	0.834
GNA13	ARHGEF11	ENSLACP00000019021	ENSLACP00000002825	G protein subunit alpha 13.	Rho guanine nucleotide exchange factor 11.	0.834
GNA13	ARHGEF12	ENSLACP00000019021	ENSLACP00000010515	G protein subunit alpha 13.	Rho guanine nucleotide exchange factor 12.	0.834
GNA13	GNA12	ENSLACP00000019021	ENSLACP00000006367	G protein subunit alpha 13.	G protein subunit alpha 12.	0.870