STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAXIP1PAX interacting protein 1. (1219 aa)    
Predicted Functional Partners:
TP53BP1
Tumor protein p53 binding protein 1.
    
 0.985
ATM
ATM serine/threonine kinase.
   
 0.982
SMC6
Structural maintenance of chromosomes 6.
   
 
 0.969
NBN
Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
    
 0.968
SLF1
SMC5-SMC6 complex localization factor 1.
   
 0.967
KDM6A
Lysine (K)-specific demethylase 6A.
    
 0.958
TOPBP1
DNA topoisomerase II binding protein 1.
   
 
0.948
KDM6B
Lysine demethylase 6B.
    
 0.946
PWWP2A
PWWP domain containing 2A.
   
 0.944
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.931
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.