Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SOCS2Suppressor of cytokine signaling 2. (176 aa)    
Predicted Functional Partners:
ELOC
Elongin C; Belongs to the SKP1 family.
    
 0.993
CUL5
Cullin 5; Belongs to the cullin family.
   
 0.991
GHR
Growth hormone receptor.
    
 0.984
SOCS6
Suppressor of cytokine signaling 6.
     
0.878
SOCS4
Suppressor of cytokine signaling 4.
     
 0.871
CISH
Cytokine inducible SH2 containing protein.
   
0.838
H3B5A0_LATCH
Fibronectin type-III domain-containing protein.
    
 
 0.816
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.
     
 0.800
SOCS5
Suppressor of cytokine signaling 5.
     
0.791
SOCS1
Suppressor of cytokine signaling 1a.
    
0.778
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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