MARCHF3 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MARCHF3

Membrane associated ring-CH-type finger 3. (252 aa)

Predicted Functional Partners:

H3AC12_LATCH

0.578

STX10

0.562

STX6

0.562

UBE2G2

0.548

CNOT2

0.514

CFTR

0.499

UBR1

0.496

C1QTNF12

0.493

UBE2J2

0.493

MARCHF5

0.492

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QTNF12	MARCHF3	ENSLACP00000021290	ENSLACP00000006535	C1q and TNF related 12.	Membrane associated ring-CH-type finger 3.	0.493
C1QTNF12	UBE2G2	ENSLACP00000021290	ENSLACP00000016288	C1q and TNF related 12.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.890
CFTR	MARCHF3	ENSLACP00000003335	ENSLACP00000006535	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Membrane associated ring-CH-type finger 3.	0.499
CNOT2	MARCHF3	ENSLACP00000007928	ENSLACP00000006535	CCR4-NOT transcription complex subunit 2.	Membrane associated ring-CH-type finger 3.	0.514
CNOT2	UBE2G2	ENSLACP00000007928	ENSLACP00000016288	CCR4-NOT transcription complex subunit 2.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.839
H3AC12_LATCH	MARCHF3	ENSLACP00000007183	ENSLACP00000006535	RNase_Zc3h12a domain-containing protein.	Membrane associated ring-CH-type finger 3.	0.578
MARCHF3	C1QTNF12	ENSLACP00000006535	ENSLACP00000021290	Membrane associated ring-CH-type finger 3.	C1q and TNF related 12.	0.493
MARCHF3	CFTR	ENSLACP00000006535	ENSLACP00000003335	Membrane associated ring-CH-type finger 3.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.499
MARCHF3	CNOT2	ENSLACP00000006535	ENSLACP00000007928	Membrane associated ring-CH-type finger 3.	CCR4-NOT transcription complex subunit 2.	0.514
MARCHF3	H3AC12_LATCH	ENSLACP00000006535	ENSLACP00000007183	Membrane associated ring-CH-type finger 3.	RNase_Zc3h12a domain-containing protein.	0.578
MARCHF3	MARCHF5	ENSLACP00000006535	ENSLACP00000014008	Membrane associated ring-CH-type finger 3.	Membrane associated ring-CH-type finger 5.	0.492
MARCHF3	STX10	ENSLACP00000006535	ENSLACP00000016013	Membrane associated ring-CH-type finger 3.	Syntaxin 10.	0.562
MARCHF3	STX6	ENSLACP00000006535	ENSLACP00000017708	Membrane associated ring-CH-type finger 3.	Syntaxin 6; Belongs to the syntaxin family.	0.562
MARCHF3	UBE2G2	ENSLACP00000006535	ENSLACP00000016288	Membrane associated ring-CH-type finger 3.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.548
MARCHF3	UBE2J2	ENSLACP00000006535	ENSLACP00000021317	Membrane associated ring-CH-type finger 3.	Ubiquitin conjugating enzyme E2 J2.	0.493
MARCHF3	UBR1	ENSLACP00000006535	ENSLACP00000001074	Membrane associated ring-CH-type finger 3.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.496
MARCHF5	MARCHF3	ENSLACP00000014008	ENSLACP00000006535	Membrane associated ring-CH-type finger 5.	Membrane associated ring-CH-type finger 3.	0.492
STX10	MARCHF3	ENSLACP00000016013	ENSLACP00000006535	Syntaxin 10.	Membrane associated ring-CH-type finger 3.	0.562
STX6	MARCHF3	ENSLACP00000017708	ENSLACP00000006535	Syntaxin 6; Belongs to the syntaxin family.	Membrane associated ring-CH-type finger 3.	0.562
UBE2G2	C1QTNF12	ENSLACP00000016288	ENSLACP00000021290	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	C1q and TNF related 12.	0.890