STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIB3Tribbles pseudokinase 3. (353 aa)    
Predicted Functional Partners:
CHAC1
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
   
 
 0.894
ATF4
Activating transcription factor 4.
    
 0.843
COP1
COP1 E3 ubiquitin ligase.
    
 
 0.804
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
   
0.764
AKT2
AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.
   
0.764
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
 
 
0.764
PRKAB2
Protein kinase AMP-activated non-catalytic subunit beta 2.
    
 0.694
PRKAB1
Protein kinase AMP-activated non-catalytic subunit beta 1.
    
 0.694
STK40
Serine/threonine kinase 40.
    
 
0.676
PRKAG2
Protein kinase AMP-activated non-catalytic subunit gamma 2.
   
 0.670
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.