MEIS1 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MEIS1

Meis homeobox 1. (466 aa)

Predicted Functional Partners:

HOXA9

0.878

TSHZ3

0.818

FAM222A

0.756

PBX1

0.744

HOXB6

0.737

HOXC9

0.735

DLX3

0.730

PBX3

0.730

EN1

0.726

H3AM53_LATCH

0.693

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

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same PNG format, but at higher resolution

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLX3	HOXB6	ENSLACP00000016393	ENSLACP00000017030	Distal-less homeobox 3.	Homeobox B6.	0.436
DLX3	MEIS1	ENSLACP00000016393	ENSLACP00000006547	Distal-less homeobox 3.	Meis homeobox 1.	0.730
EN1	H3AM53_LATCH	ENSLACP00000019687	ENSLACP00000010724	Homeobox protein engrailed-like.	PBC domain-containing protein.	0.446
EN1	MEIS1	ENSLACP00000019687	ENSLACP00000006547	Homeobox protein engrailed-like.	Meis homeobox 1.	0.726
EN1	PBX1	ENSLACP00000019687	ENSLACP00000014235	Homeobox protein engrailed-like.	PBX homeobox 1.	0.446
EN1	PBX3	ENSLACP00000019687	ENSLACP00000020234	Homeobox protein engrailed-like.	Pre-B-cell leukemia homeobox 3a.	0.446
FAM222A	H3AM53_LATCH	ENSLACP00000002134	ENSLACP00000010724	Family with sequence similarity 222 member A.	PBC domain-containing protein.	0.525
FAM222A	MEIS1	ENSLACP00000002134	ENSLACP00000006547	Family with sequence similarity 222 member A.	Meis homeobox 1.	0.756
FAM222A	PBX1	ENSLACP00000002134	ENSLACP00000014235	Family with sequence similarity 222 member A.	PBX homeobox 1.	0.525
FAM222A	PBX3	ENSLACP00000002134	ENSLACP00000020234	Family with sequence similarity 222 member A.	Pre-B-cell leukemia homeobox 3a.	0.525
H3AM53_LATCH	EN1	ENSLACP00000010724	ENSLACP00000019687	PBC domain-containing protein.	Homeobox protein engrailed-like.	0.446
H3AM53_LATCH	FAM222A	ENSLACP00000010724	ENSLACP00000002134	PBC domain-containing protein.	Family with sequence similarity 222 member A.	0.525
H3AM53_LATCH	HOXA9	ENSLACP00000010724	ENSLACP00000019754	PBC domain-containing protein.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.634
H3AM53_LATCH	HOXB6	ENSLACP00000010724	ENSLACP00000017030	PBC domain-containing protein.	Homeobox B6.	0.765
H3AM53_LATCH	HOXC9	ENSLACP00000010724	ENSLACP00000018958	PBC domain-containing protein.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.671
H3AM53_LATCH	MEIS1	ENSLACP00000010724	ENSLACP00000006547	PBC domain-containing protein.	Meis homeobox 1.	0.693
H3AM53_LATCH	PBX1	ENSLACP00000010724	ENSLACP00000014235	PBC domain-containing protein.	PBX homeobox 1.	0.838
H3AM53_LATCH	PBX3	ENSLACP00000010724	ENSLACP00000020234	PBC domain-containing protein.	Pre-B-cell leukemia homeobox 3a.	0.809
HOXA9	H3AM53_LATCH	ENSLACP00000019754	ENSLACP00000010724	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	PBC domain-containing protein.	0.634
HOXA9	HOXC9	ENSLACP00000019754	ENSLACP00000018958	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.576