STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNKSPoly [ADP-ribose] polymerase. (1233 aa)    
Predicted Functional Partners:
RNF146
Ring finger protein 146.
    
 0.964
AXIN1
Axin 1.
    
 0.932
AXIN2
Axin 2.
    
 0.932
CLRN1
Clarin 1.
      
 0.745
MCL1
MCL1 apoptosis regulator, BCL2 family member.
    
 
 0.730
HIF1AN
Hypoxia inducible factor 1 subunit alpha inhibitor.
    
 
 0.700
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.678
TPTE2
Transmembrane phosphatase with tensin homology.
   
 0.678
GMDS
GDP-mannose 4,6-dehydratase.
    
 
 0.672
BABAM1
BRISC and BRCA1 A complex member 1.
    
 0.653
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.