STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H3AK44_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (105 aa)    
Predicted Functional Partners:
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
    
 0.877
H2AX
Histone H2A; Belongs to the histone H2A family.
  
 0.851
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.845
LOC102346364
Histone H2A; Belongs to the histone H2A family.
  
 0.799
H3A6T6_LATCH
Histone H2A; Belongs to the histone H2A family.
  
 0.798
GLYR1
Glyoxylate reductase 1 homolog.
    
   0.798
H3B8N0_LATCH
Histone H2A; Belongs to the histone H2A family.
  
 0.796
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 0.792
KDM6A
Lysine (K)-specific demethylase 6A.
    
 0.779
KDM6B
Lysine demethylase 6B.
    
 0.779
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.