STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DECR12,4-dienoyl-CoA reductase 1. (326 aa)    
Predicted Functional Partners:
FPGS
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
   
 
 0.647
ACADM
Acyl-CoA dehydrogenase medium chain.
  
 0.629
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
     
 0.624
ACAA1
Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.623
FASN
Fatty acid synthase.
  
 0.611
ECI1
Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 0.609
EHHADH
Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase.
   
 0.600
OXSM
3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 0.550
LIPC
Lipase C, hepatic type.
    
 
 0.546
AADAT
Aminoadipate aminotransferase.
   
  
 0.543
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.