H3AMM4_LATCH protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

H3AMM4_LATCH

Homeobox domain-containing protein. (194 aa)

Predicted Functional Partners:

GLIS1

0.505

H3B8Q8_LATCH

0.468

SLC30A8

0.453

PRRX1

0.443

CDKAL1

0.442

IRX1

0.433

CRX

0.422

OTX2

0.422

FTO

0.418

MKX

0.411

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKAL1	FTO	ENSLACP00000006918	ENSLACP00000008840	CDK5 regulatory subunit associated protein 1 like 1.	FTO alpha-ketoglutarate dependent dioxygenase.	0.555
CDKAL1	H3AMM4_LATCH	ENSLACP00000006918	ENSLACP00000010895	CDK5 regulatory subunit associated protein 1 like 1.	Homeobox domain-containing protein.	0.442
CDKAL1	SLC30A8	ENSLACP00000006918	ENSLACP00000017636	CDK5 regulatory subunit associated protein 1 like 1.	Uncharacterized protein.	0.605
CRX	GLIS1	ENSLACP00000014128	ENSLACP00000013799	Homeobox domain-containing protein.	GLIS family zinc finger 1.	0.436
CRX	H3AMM4_LATCH	ENSLACP00000014128	ENSLACP00000010895	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.422
FTO	CDKAL1	ENSLACP00000008840	ENSLACP00000006918	FTO alpha-ketoglutarate dependent dioxygenase.	CDK5 regulatory subunit associated protein 1 like 1.	0.555
FTO	H3AMM4_LATCH	ENSLACP00000008840	ENSLACP00000010895	FTO alpha-ketoglutarate dependent dioxygenase.	Homeobox domain-containing protein.	0.418
FTO	SLC30A8	ENSLACP00000008840	ENSLACP00000017636	FTO alpha-ketoglutarate dependent dioxygenase.	Uncharacterized protein.	0.457
GLIS1	CRX	ENSLACP00000013799	ENSLACP00000014128	GLIS family zinc finger 1.	Homeobox domain-containing protein.	0.436
GLIS1	H3AMM4_LATCH	ENSLACP00000013799	ENSLACP00000010895	GLIS family zinc finger 1.	Homeobox domain-containing protein.	0.505
GLIS1	OTX2	ENSLACP00000013799	ENSLACP00000021594	GLIS family zinc finger 1.	Orthodenticle homeobox 2.	0.564
GLIS1	PRRX1	ENSLACP00000013799	ENSLACP00000012899	GLIS family zinc finger 1.	Paired related homeobox 1.	0.565
H3AMM4_LATCH	CDKAL1	ENSLACP00000010895	ENSLACP00000006918	Homeobox domain-containing protein.	CDK5 regulatory subunit associated protein 1 like 1.	0.442
H3AMM4_LATCH	CRX	ENSLACP00000010895	ENSLACP00000014128	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.422
H3AMM4_LATCH	FTO	ENSLACP00000010895	ENSLACP00000008840	Homeobox domain-containing protein.	FTO alpha-ketoglutarate dependent dioxygenase.	0.418
H3AMM4_LATCH	GLIS1	ENSLACP00000010895	ENSLACP00000013799	Homeobox domain-containing protein.	GLIS family zinc finger 1.	0.505
H3AMM4_LATCH	H3B8Q8_LATCH	ENSLACP00000010895	ENSLACP00000018279	Homeobox domain-containing protein.	Forkhead box A3.	0.468
H3AMM4_LATCH	IRX1	ENSLACP00000010895	ENSLACP00000014722	Homeobox domain-containing protein.	Iroquois homeobox 1.	0.433
H3AMM4_LATCH	MKX	ENSLACP00000010895	ENSLACP00000007585	Homeobox domain-containing protein.	Mohawk homeobox.	0.411
H3AMM4_LATCH	OTX2	ENSLACP00000010895	ENSLACP00000021594	Homeobox domain-containing protein.	Orthodenticle homeobox 2.	0.422

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

2.22e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090151

Establishment of protein localization to mitochondrial membrane

5 of 33

2.09

3.04

4.29e-07

GO:0072655

Establishment of protein localization to mitochondrion

6 of 58

1.92

2.99

1.71e-07

GO:0006839

Mitochondrial transport

6 of 59

1.92

2.97

1.71e-07

GO:0051205

Protein insertion into membrane

5 of 45

1.95

2.72

1.20e-06

GO:0006626

Protein targeting to mitochondrion

5 of 49

1.92

2.64

1.53e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030943

Mitochondrion targeting sequence binding

2 of 4

2.61

0.83

0.0307

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032592

Integral component of mitochondrial membrane

6 of 48

2.0

3.49

1.42e-08

GO:0005741

Mitochondrial outer membrane

6 of 54

1.95

3.41

1.42e-08

GO:0031307

Integral component of mitochondrial outer membrane

4 of 14

2.36

3.21

5.35e-07

GO:0031966

Mitochondrial membrane

7 of 306

1.27

1.6

1.52e-06

GO:0000127

Transcription factor TFIIIC complex

2 of 4

2.61

1.59

0.0012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9394

Protein localization to mitochondrion, and Mitochondrial calcium ion transport

5 of 41

1.99

2.66

2.14e-06

CL:9397

Protein import into mitochondrial matrix, and Tim10-like

3 of 22

2.04

1.57

0.00085

CL:9426

Mitochondrial outer membrane translocase complex

2 of 5

2.51

1.19

0.0067

CL:1471

Transcription factor TFIIIC complex

2 of 5

2.51

1.19

0.0067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031307

Integral component of mitochondrial outer membrane

4 of 11

2.47

3.41

2.79e-07

GOCC:0032592

Integral component of mitochondrial membrane

5 of 33

2.09

3.18

1.90e-07

GOCC:0005741

Mitochondrial outer membrane

6 of 74

1.82

2.81

1.90e-07

GOCC:0031966

Mitochondrial membrane

7 of 241

1.37

1.88

4.38e-07

GOCC:0005742

Mitochondrial outer membrane translocase complex

2 of 5

2.51

1.53

0.0015

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About