STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAPGEF5Rap guanine nucleotide exchange factor 5. (368 aa)    
Predicted Functional Partners:
LOC102351219
Rap guanine nucleotide exchange factor (GEF) 3.
 
    
 0.903
NLK
Mitogen-activated protein kinase.
      
 0.759
RAPGEFL1
Rap guanine nucleotide exchange factor like 1.
  
 
 
0.654
ILK
Integrin linked kinase.
      
 0.573
LRP5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
      
 0.502
CKAP5
Cytoskeleton associated protein 5.
      
 0.495
CLCN6
Chloride voltage-gated channel 6; Belongs to the chloride channel (TC 2.A.49) family.
      
 0.485
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 
0.485
MRAS
Uncharacterized protein.
    
 0.473
LOC102356108
Uncharacterized protein.
    
 0.473
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.