STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRKCRK proto-oncogene, adaptor protein. (310 aa)    
Predicted Functional Partners:
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.983
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 0.973
GRB2
Growth factor receptor bound protein 2.
    
0.906
FRS2
Fibroblast growth factor receptor substrate 2.
    
 0.902
CBLB
Cbl proto-oncogene B.
    
 0.894
H3AWW7_LATCH
Uncharacterized protein.
    
 0.894
CBL
Cbl proto-oncogene.
    
 0.894
ABL2
Tyrosine-protein kinase.
    
 0.853
ABL1
Tyrosine-protein kinase.
    
 0.853
GAB1
GRB2 associated binding protein 1.
    
 0.850
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.