STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COP1COP1 E3 ubiquitin ligase. (702 aa)    
Predicted Functional Partners:
ERCC8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit.
    
  0.962
DDB1
Damage specific DNA binding protein 1.
    
 0.933
H3BGC1_LATCH
DET1 partner of COP1 E3 ubiquitin ligase.
    
 
 0.894
ATM
ATM serine/threonine kinase.
    
 0.886
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.880
RBX1
Ring-box 1.
    
 0.822
TRIB3
Tribbles pseudokinase 3.
    
 
 0.804
ETV5
ETS variant 5.
    
 
 0.790
CUL4A
Cullin 4A; Belongs to the cullin family.
    
 0.776
CUL4B
Cullin 4B; Belongs to the cullin family.
    
 0.776
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.