STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCAR2Cell cycle and apoptosis regulator 2. (942 aa)    
Predicted Functional Partners:
SIRT6
Sirtuin 6.
    
 0.662
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
    
 0.601
SIRT1
Sirtuin 1.
    
 0.601
CHEK2
Checkpoint kinase 2.
    
 
 0.569
TCERG1
Transcription elongation regulator 1.
   
 
  0.543
SRRT
Serrate, RNA effector molecule.
   
 
 0.493
HPDL
4-hydroxyphenylpyruvate dioxygenase.
     
 0.467
LOC102364955
4-hydroxyphenylpyruvate dioxygenase.
     
 0.467
SIRT7
Sirtuin 7.
    
 0.462
PPCS
Phosphopantothenoylcysteine synthetase.
      
 0.424
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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