STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TWIST2Twist family bHLH transcription factor 2. (161 aa)    
Predicted Functional Partners:
HDAC7
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
   
 
 0.597
VSTM2L
V-set and transmembrane domain containing 2 like.
      
 0.578
CTNNA1
Catenin (cadherin-associated protein), alpha 1.
      
 0.573
CYP26B1
Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.
   
  
 0.549
SCAMP5
Secretory carrier-associated membrane protein.
      
 0.536
ESRP1
Uncharacterized protein.
      
 0.499
REL
REL proto-oncogene, NF-kB subunit.
   
 
 0.481
H3B111_LATCH
V-rel avian reticuloendotheliosis viral oncogene homolog A.
   
 
 0.481
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.481
TCF4
Transcription factor 4.
    
 
 0.467
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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