H3AYY3_LATCH protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

H3AYY3_LATCH

Uncharacterized protein. (223 aa)

Predicted Functional Partners:

BRCC3

0.730

BABAM1

0.729

BRCA1

0.660

RPS27A

0.610

BARD1

0.591

FAU

0.565

PAXIP1

0.527

H3A1J4_LATCH

0.519

H3B5K4_LATCH

0.510

H3B4Y6_LATCH

0.505

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BABAM1	BARD1	ENSLACP00000011010	ENSLACP00000022324	BRISC and BRCA1 A complex member 1.	BRCA1 associated RING domain 1.	0.980
BABAM1	BRCA1	ENSLACP00000011010	ENSLACP00000006740	BRISC and BRCA1 A complex member 1.	BRCA1 DNA repair associated.	0.988
BABAM1	BRCC3	ENSLACP00000011010	ENSLACP00000016740	BRISC and BRCA1 A complex member 1.	BRCA1/BRCA2-containing complex subunit 3.	0.999
BABAM1	H3AYY3_LATCH	ENSLACP00000011010	ENSLACP00000014854	BRISC and BRCA1 A complex member 1.	Uncharacterized protein.	0.729
BABAM1	PAXIP1	ENSLACP00000011010	ENSLACP00000006504	BRISC and BRCA1 A complex member 1.	PAX interacting protein 1.	0.722
BABAM1	RPS27A	ENSLACP00000011010	ENSLACP00000008678	BRISC and BRCA1 A complex member 1.	Ribosomal protein S27a.	0.596
BARD1	BABAM1	ENSLACP00000022324	ENSLACP00000011010	BRCA1 associated RING domain 1.	BRISC and BRCA1 A complex member 1.	0.980
BARD1	BRCA1	ENSLACP00000022324	ENSLACP00000006740	BRCA1 associated RING domain 1.	BRCA1 DNA repair associated.	0.999
BARD1	BRCC3	ENSLACP00000022324	ENSLACP00000016740	BRCA1 associated RING domain 1.	BRCA1/BRCA2-containing complex subunit 3.	0.925
BARD1	FAU	ENSLACP00000022324	ENSLACP00000008505	BRCA1 associated RING domain 1.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.777
BARD1	H3AYY3_LATCH	ENSLACP00000022324	ENSLACP00000014854	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.591
BARD1	PAXIP1	ENSLACP00000022324	ENSLACP00000006504	BRCA1 associated RING domain 1.	PAX interacting protein 1.	0.921
BARD1	RPS27A	ENSLACP00000022324	ENSLACP00000008678	BRCA1 associated RING domain 1.	Ribosomal protein S27a.	0.936
BRCA1	BABAM1	ENSLACP00000006740	ENSLACP00000011010	BRCA1 DNA repair associated.	BRISC and BRCA1 A complex member 1.	0.988
BRCA1	BARD1	ENSLACP00000006740	ENSLACP00000022324	BRCA1 DNA repair associated.	BRCA1 associated RING domain 1.	0.999
BRCA1	BRCC3	ENSLACP00000006740	ENSLACP00000016740	BRCA1 DNA repair associated.	BRCA1/BRCA2-containing complex subunit 3.	0.956
BRCA1	FAU	ENSLACP00000006740	ENSLACP00000008505	BRCA1 DNA repair associated.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.420
BRCA1	H3AYY3_LATCH	ENSLACP00000006740	ENSLACP00000014854	BRCA1 DNA repair associated.	Uncharacterized protein.	0.660
BRCA1	PAXIP1	ENSLACP00000006740	ENSLACP00000006504	BRCA1 DNA repair associated.	PAX interacting protein 1.	0.898
BRCA1	RPS27A	ENSLACP00000006740	ENSLACP00000008678	BRCA1 DNA repair associated.	Ribosomal protein S27a.	0.733

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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