TBCB protein (Latimeria chalumnae) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

TBCB

Tubulin folding cofactor B. (246 aa)

Predicted Functional Partners:

TBCE

0.846

H3A466_LATCH

0.728

TBCA

0.717

TBCEL

0.700

TBCC

0.685

GAN

0.660

TRAPPC4

0.610

PTGES3L

0.555

RP2

0.539

H3A984_LATCH

0.539

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAN	TBCB	ENSLACP00000010541	ENSLACP00000014866	Gigaxonin.	Tubulin folding cofactor B.	0.660
H3A466_LATCH	H3A984_LATCH	ENSLACP00000004437	ENSLACP00000006205	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.878
H3A466_LATCH	RP2	ENSLACP00000004437	ENSLACP00000005661	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.	0.512
H3A466_LATCH	TBCA	ENSLACP00000004437	ENSLACP00000017781	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin-specific chaperone A; Belongs to the TBCA family.	0.603
H3A466_LATCH	TBCB	ENSLACP00000004437	ENSLACP00000014866	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor B.	0.728
H3A466_LATCH	TBCC	ENSLACP00000004437	ENSLACP00000020092	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor C.	0.626
H3A466_LATCH	TBCE	ENSLACP00000004437	ENSLACP00000014382	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	CAP-Gly domain-containing protein.	0.717
H3A466_LATCH	TBCEL	ENSLACP00000004437	ENSLACP00000022012	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor E-like b.	0.436
H3A984_LATCH	H3A466_LATCH	ENSLACP00000006205	ENSLACP00000004437	Uncharacterized protein.	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	0.878
H3A984_LATCH	RP2	ENSLACP00000006205	ENSLACP00000005661	Uncharacterized protein.	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.	0.433
H3A984_LATCH	TBCA	ENSLACP00000006205	ENSLACP00000017781	Uncharacterized protein.	Tubulin-specific chaperone A; Belongs to the TBCA family.	0.518
H3A984_LATCH	TBCB	ENSLACP00000006205	ENSLACP00000014866	Uncharacterized protein.	Tubulin folding cofactor B.	0.539
H3A984_LATCH	TBCC	ENSLACP00000006205	ENSLACP00000020092	Uncharacterized protein.	Tubulin folding cofactor C.	0.553
H3A984_LATCH	TBCE	ENSLACP00000006205	ENSLACP00000014382	Uncharacterized protein.	CAP-Gly domain-containing protein.	0.812
H3A984_LATCH	TBCEL	ENSLACP00000006205	ENSLACP00000022012	Uncharacterized protein.	Tubulin folding cofactor E-like b.	0.424
PTGES3L	TBCB	ENSLACP00000007820	ENSLACP00000014866	Alanyl-tRNA synthetase domain containing 1.	Tubulin folding cofactor B.	0.555
RP2	H3A466_LATCH	ENSLACP00000005661	ENSLACP00000004437	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	0.512
RP2	H3A984_LATCH	ENSLACP00000005661	ENSLACP00000006205	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.	Uncharacterized protein.	0.433
RP2	TBCA	ENSLACP00000005661	ENSLACP00000017781	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.	Tubulin-specific chaperone A; Belongs to the TBCA family.	0.538
RP2	TBCB	ENSLACP00000005661	ENSLACP00000014866	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.	Tubulin folding cofactor B.	0.539

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0522

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099560

Synaptic membrane adhesion

5 of 12

2.84

4.76

1.30e-09

GO:0035335

Peptidyl-tyrosine dephosphorylation

4 of 27

2.39

2.73

5.75e-06

GO:0019221

Cytokine-mediated signaling pathway

6 of 181

1.74

2.39

1.81e-06

GO:0097374

Sensory neuron axon guidance

2 of 4

2.92

1.36

0.0035

GO:0070498

interleukin-1-mediated signaling pathway

2 of 7

2.68

1.21

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004908

interleukin-1 receptor activity

4 of 4

3.22

4.35

1.23e-08

GO:0061809

NAD+ nucleotidase, cyclic ADP-ribose generating

3 of 15

2.52

2.13

0.00011

GO:0050135

NAD(P)+ nucleosidase activity

3 of 15

2.52

2.13

0.00011

GO:0004725

Protein tyrosine phosphatase activity

4 of 97

1.84

1.86

0.00011

GO:0008201

Heparin binding

4 of 114

1.77

1.75

0.00016

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34025644

(2021) Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.

3 of 39

2.11

1.48

0.0014

PMID:27231948

(2016) The Function of Fish Cytokines.

3 of 40

2.1

1.48

0.0014

PMID:35371107

(2022) Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-gamma in Chinese Sturgeon Macrophages.

2 of 12

2.44

1.16

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4439

NAD+ nucleosidase activity, and interleukin-1-mediated signaling pathway

6 of 17

2.77

6.02

3.38e-12

CL:4443

interleukin-1-mediated signaling pathway, and Inflammatory response

4 of 5

3.13

4.47

6.78e-09

CL:7095

Receptor-type tyrosine-protein phosphatases, and Synaptic membrane adhesion

4 of 21

2.5

3.38

3.39e-07

CL:7097

Synaptic membrane adhesion, and Presynaptic membrane assembly

3 of 13

2.59

2.46

2.65e-05

CL:7099

Synaptic membrane adhesion, and NTF3 activates NTRK3 signaling

2 of 5

2.82

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

4 of 105

1.8

1.9

7.30e-05

map04910

Insulin signaling pathway

4 of 157

1.63

1.68

0.00012

map04620

Toll-like receptor signaling pathway

3 of 91

1.74

1.49

0.00067

map04514

Cell adhesion molecules

4 of 210

1.5

1.46

0.00027

map04010

MAPK signaling pathway

5 of 361

1.36

1.41

0.00012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-388844

Receptor-type tyrosine-protein phosphatases

5 of 24

2.54

4.43

2.60e-09

MAP-446652

Interleukin-1 family signaling

7 of 108

2.03

4.21

1.69e-10

MAP-8849932

Synaptic adhesion-like molecules

4 of 21

2.5

3.37

3.63e-07

MAP-6794362

Protein-protein interactions at synapses

5 of 89

1.97

2.89

4.72e-07

MAP-9020702

Interleukin-1 signaling

5 of 95

1.94

2.83

5.39e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 70

1.85

1.25

0.0032

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004074

Interleukin-1 receptor type I/II

4 of 7

2.98

3.72

1.52e-07

IPR015621

Interleukin-1 receptor family

4 of 10

2.82

3.59

2.31e-07

IPR000157

Toll/interleukin-1 receptor homology (TIR) domain

3 of 29

2.24

1.68

0.00065

IPR035897

Toll/interleukin-1 receptor homology (TIR) domain superfamily

3 of 31

2.21

1.65

0.00070

IPR003598

Immunoglobulin subtype 2

5 of 245

1.53

1.52

0.00021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00194

Protein tyrosine phosphatase, catalytic domain

3 of 39

2.11

1.59

0.00085

SM00409

Immunoglobulin

5 of 351

1.38

1.2

0.00085

SM00255

Toll - interleukin 1 - resistance

2 of 14

2.38

1.09

0.0098

SM00408

Immunoglobulin C-2 Type

3 of 206

1.39

0.67

0.0378

SM00060

Fibronectin type 3 domain

3 of 198

1.4

0.67

0.0378

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