PLAT protein (Latimeria chalumnae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

PLAT

Plasminogen activator; Belongs to the peptidase S1 family. (552 aa)

Predicted Functional Partners:

SERPINE1

0.989

ANXA2

0.894

LOC102363099

0.886

SERPINE2

0.886

SERPINF2

0.844

PLG

0.841

H2ZX70_LATCH

0.835

H3A3U7_LATCH

0.835

LOC102356587

0.820

PDGFC

0.719

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA2	LOC102356587	ENSLACP00000020038	ENSLACP00000002593	Annexin.	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.671
ANXA2	LOC102363099	ENSLACP00000020038	ENSLACP00000004210	Annexin.	S_100 domain-containing protein; Belongs to the S-100 family.	0.999
ANXA2	PLAT	ENSLACP00000020038	ENSLACP00000015011	Annexin.	Plasminogen activator; Belongs to the peptidase S1 family.	0.894
ANXA2	PLG	ENSLACP00000020038	ENSLACP00000023309	Annexin.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.671
ANXA2	SERPINE1	ENSLACP00000020038	ENSLACP00000006192	Annexin.	Serpin family E member 1; Belongs to the serpin family.	0.430
H2ZX70_LATCH	PLAT	ENSLACP00000001991	ENSLACP00000015011	Uncharacterized protein.	Plasminogen activator; Belongs to the peptidase S1 family.	0.835
H3A3U7_LATCH	PLAT	ENSLACP00000004318	ENSLACP00000015011	Uncharacterized protein.	Plasminogen activator; Belongs to the peptidase S1 family.	0.835
LOC102356587	ANXA2	ENSLACP00000002593	ENSLACP00000020038	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	Annexin.	0.671
LOC102356587	LOC102363099	ENSLACP00000002593	ENSLACP00000004210	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	S_100 domain-containing protein; Belongs to the S-100 family.	0.653
LOC102356587	PDGFC	ENSLACP00000002593	ENSLACP00000023425	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.471
LOC102356587	PLAT	ENSLACP00000002593	ENSLACP00000015011	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	Plasminogen activator; Belongs to the peptidase S1 family.	0.820
LOC102356587	SERPINE1	ENSLACP00000002593	ENSLACP00000006192	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	Serpin family E member 1; Belongs to the serpin family.	0.627
LOC102356587	SERPINE2	ENSLACP00000002593	ENSLACP00000005293	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	Serpin family E member 2; Belongs to the serpin family.	0.462
LOC102356587	SERPINF2	ENSLACP00000002593	ENSLACP00000003724	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	Serpin family F member 2; Belongs to the serpin family.	0.894
LOC102363099	ANXA2	ENSLACP00000004210	ENSLACP00000020038	S_100 domain-containing protein; Belongs to the S-100 family.	Annexin.	0.999
LOC102363099	LOC102356587	ENSLACP00000004210	ENSLACP00000002593	S_100 domain-containing protein; Belongs to the S-100 family.	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.653
LOC102363099	PLAT	ENSLACP00000004210	ENSLACP00000015011	S_100 domain-containing protein; Belongs to the S-100 family.	Plasminogen activator; Belongs to the peptidase S1 family.	0.886
LOC102363099	PLG	ENSLACP00000004210	ENSLACP00000023309	S_100 domain-containing protein; Belongs to the S-100 family.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.653
PDGFC	LOC102356587	ENSLACP00000023425	ENSLACP00000002593	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.471
PDGFC	PLAT	ENSLACP00000023425	ENSLACP00000015011	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	Plasminogen activator; Belongs to the peptidase S1 family.	0.719

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.794

expected number of edges:

13

PPI enrichment p-value:

0.0158

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

6 of 86

1.45

1.61

4.69e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004556

Alpha-amylase activity

2 of 2

2.61

0.83

0.0314

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31379757

(2019) Hydrostatic Pressure Helps to Cultivate an Original Anaerobic Bacterium From the Atlantis Massif Subseafloor (IODP Expedition 357): Petrocella atlantisensis gen. nov. sp. nov.

3 of 3

2.61

1.97

0.00023

PMID:36303868

(2022) White common bean extract remodels the gut microbiota and ameliorates type 2 diabetes and its complications: A randomized double-blinded placebo-controlled trial.

2 of 2

2.61

0.97

0.0176

PMID:30100182

(2018) Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen.

2 of 3

2.43

0.94

0.0195

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3649

This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins., and Electron transport

6 of 10

2.39

4.69

3.40e-10

CL:3652

Mixed, incl. RnfC Barrel sandwich hybrid domain, and This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins.

5 of 5

2.61

4.39

4.00e-09

CL:5617

Alpha-amylase domain, and Glycosyl hydrolases family 31

2 of 5

2.21

0.83

0.0296

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

6 of 31

1.9

3.23

2.43e-08

KW-1278

Translocase

5 of 43

1.67

2.13

6.56e-06

KW-0106

Calcium

2 of 8

2.01

1.0

0.0127

KW-0997

Cell inner membrane

5 of 162

1.1

0.87

0.0023

KW-0004

4Fe-4S

3 of 58

1.32

0.78

0.0160

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00642

Alpha-amylase domain

2 of 4

2.31

1.04

0.0118

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