DDX42 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

DDX42

DEAD-box helicase 42. (923 aa)

Predicted Functional Partners:

SF3B5

0.999

SF3B3

0.999

SF3B1

0.999

SF3B4

0.998

SF3B6

0.996

PHF5A

0.994

SF3B2

0.979

SF3A2

0.962

DHX15

0.880

ZMAT5

0.852

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX42	DHX15	ENSLACP00000015308	ENSLACP00000008161	DEAD-box helicase 42.	DEAH-box helicase 15.	0.880
DDX42	PHF5A	ENSLACP00000015308	ENSLACP00000013739	DEAD-box helicase 42.	PHD finger protein 5A.	0.994
DDX42	SF3A2	ENSLACP00000015308	ENSLACP00000009919	DEAD-box helicase 42.	Splicing factor 3a subunit 2.	0.962
DDX42	SF3B1	ENSLACP00000015308	ENSLACP00000016839	DEAD-box helicase 42.	Splicing factor 3b subunit 1.	0.999
DDX42	SF3B2	ENSLACP00000015308	ENSLACP00000011850	DEAD-box helicase 42.	Splicing factor 3b subunit 2.	0.979
DDX42	SF3B3	ENSLACP00000015308	ENSLACP00000014198	DEAD-box helicase 42.	Splicing factor 3b subunit 3.	0.999
DDX42	SF3B4	ENSLACP00000015308	ENSLACP00000004989	DEAD-box helicase 42.	Splicing factor 3b subunit 4.	0.998
DDX42	SF3B5	ENSLACP00000015308	ENSLACP00000001057	DEAD-box helicase 42.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.999
DDX42	SF3B6	ENSLACP00000015308	ENSLACP00000016260	DEAD-box helicase 42.	Splicing factor 3b subunit 6.	0.996
DDX42	ZMAT5	ENSLACP00000015308	ENSLACP00000022912	DEAD-box helicase 42.	Zinc finger matrin-type 5.	0.852
DHX15	DDX42	ENSLACP00000008161	ENSLACP00000015308	DEAH-box helicase 15.	DEAD-box helicase 42.	0.880
DHX15	PHF5A	ENSLACP00000008161	ENSLACP00000013739	DEAH-box helicase 15.	PHD finger protein 5A.	0.985
DHX15	SF3A2	ENSLACP00000008161	ENSLACP00000009919	DEAH-box helicase 15.	Splicing factor 3a subunit 2.	0.911
DHX15	SF3B1	ENSLACP00000008161	ENSLACP00000016839	DEAH-box helicase 15.	Splicing factor 3b subunit 1.	0.963
DHX15	SF3B2	ENSLACP00000008161	ENSLACP00000011850	DEAH-box helicase 15.	Splicing factor 3b subunit 2.	0.855
DHX15	SF3B3	ENSLACP00000008161	ENSLACP00000014198	DEAH-box helicase 15.	Splicing factor 3b subunit 3.	0.890
DHX15	SF3B4	ENSLACP00000008161	ENSLACP00000004989	DEAH-box helicase 15.	Splicing factor 3b subunit 4.	0.871
DHX15	SF3B5	ENSLACP00000008161	ENSLACP00000001057	DEAH-box helicase 15.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.779
DHX15	SF3B6	ENSLACP00000008161	ENSLACP00000016260	DEAH-box helicase 15.	Splicing factor 3b subunit 6.	0.792
PHF5A	DDX42	ENSLACP00000013739	ENSLACP00000015308	PHD finger protein 5A.	DEAD-box helicase 42.	0.994

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.825

expected number of edges:

15

PPI enrichment p-value:

0.000447

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072522

Purine-containing compound biosynthetic process

9 of 130

2.02

5.15

9.52e-14

GO:0009152

Purine ribonucleotide biosynthetic process

7 of 116

1.96

3.93

3.73e-10

GO:0009165

Nucleotide biosynthetic process

8 of 182

1.82

3.74

9.16e-11

GO:0043101

Purine-containing compound salvage

4 of 14

2.63

3.63

1.42e-07

GO:0015986

Proton motive force-driven ATP synthesis

4 of 21

2.46

3.26

5.41e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

3 of 10

2.65

2.03

0.00018

GO:0015078

Proton transmembrane transporter activity

4 of 103

1.77

1.55

0.00052

GO:0004731

Purine-nucleoside phosphorylase activity

2 of 3

3.0

1.45

0.0024

GO:0016874

Ligase activity

4 of 151

1.6

1.26

0.0017

GO:0016763

Pentosyltransferase activity

3 of 57

1.9

1.24

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 18

2.52

3.13

1.19e-06

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 6

2.88

2.74

9.43e-06

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 4

2.88

1.59

0.0013

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

2 of 12

2.4

1.2

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8346

Mitochondrial proton-transporting ATP synthase complex

4 of 19

2.5

2.88

3.46e-06

CL:8374

CF(1), and Mitochondrial depolarization

2 of 5

2.78

1.21

0.0063

CL:24274

Mixed, incl. Pentraxin / C-reactive protein / pentaxin family, and Guanine salvage

2 of 11

2.44

0.94

0.0194

CL:8347

Mitochondrial proton-transporting ATP synthase complex

2 of 14

2.33

0.9

0.0223

CL:11211

Purine ribonucleoside monophosphate biosynthetic process, and GMP reductase complex

2 of 15

2.3

0.9

0.0225

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

5 of 218

1.54

1.76

3.21e-05

map00190

Oxidative phosphorylation

4 of 183

1.52

1.37

0.00057

map04714

Thermogenesis

4 of 229

1.42

1.22

0.0010

map05012

Parkinson disease

4 of 244

1.39

1.2

0.0010

map05020

Prion disease

4 of 266

1.35

1.15

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

4 of 18

2.52

3.26

6.50e-07

MAP-8949613

Cristae formation

4 of 27

2.35

2.95

1.86e-06

MAP-1592230

Mitochondrial biogenesis

4 of 51

2.07

2.42

1.20e-05

MAP-15869

Metabolism of nucleotides

5 of 123

1.79

2.31

4.82e-06

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

4 of 140

1.63

1.47

0.00049

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

4 of 21

2.46

2.95

2.40e-06

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 7

2.81

2.62

1.58e-05

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

2 of 9

2.52

1.15

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0660

Purine salvage

2 of 3

3.0

1.58

0.0014

KW-0139

CF(1)

2 of 3

3.0

1.58

0.0014

KW-0658

Purine biosynthesis

2 of 4

2.88

1.57

0.0014

KW-0375

Hydrogen ion transport

2 of 22

2.14

1.17

0.0062

KW-0328

Glycosyltransferase

3 of 122

1.57

1.08

0.0045

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01048

Phosphorylase superfamily

2 of 4

2.88

1.06

0.0124

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035994

Nucleoside phosphorylase superfamily

2 of 3

3.0

1.12

0.0096

IPR018099

Purine phosphorylase, family 2, conserved site

2 of 2

3.18

1.12

0.0096

IPR000845

Nucleoside phosphorylase domain

2 of 3

3.0

1.12

0.0096

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