STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOX4TOX high mobility group box family member 4. (626 aa)    
Predicted Functional Partners:
CHD8
Chromodomain helicase DNA binding protein 8.
    
 0.802
SALL2
Uncharacterized protein.
    
 
 0.749
STARD3NL
STARD3 N-terminal like.
      
 0.744
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.
    
 
 0.704
ACTR8
Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.
    
 0.692
GTF2H1
General transcription factor IIH subunit 1.
    
 0.667
HNRNPC
RRM domain-containing protein.
   
 0.665
EPDR1
Ependymin related 1.
      
 0.663
POLRMT
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.
    
 0.645
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
   
 0.645
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.