FAAH2 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FAAH2

Fatty acid amide hydrolase 2. (534 aa)

Predicted Functional Partners:

GATB

0.978

EPRS1

0.952

DARS2

0.856

EARS2

0.686

QARS1

0.686

RPL39

0.686

TMEM109

0.667

ASNSD1

0.659

GMPS

0.649

YARS1

0.620

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNSD1	DARS2	ENSLACP00000015491	ENSLACP00000013454	Asparagine synthetase domain containing 1.	Aspartyl-tRNA synthetase 2, mitochondrial.	0.609
ASNSD1	EARS2	ENSLACP00000015491	ENSLACP00000001045	Asparagine synthetase domain containing 1.	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.572
ASNSD1	EPRS1	ENSLACP00000015491	ENSLACP00000013372	Asparagine synthetase domain containing 1.	Glutamyl-prolyl-tRNA synthetase.	0.613
ASNSD1	FAAH2	ENSLACP00000015491	ENSLACP00000017097	Asparagine synthetase domain containing 1.	Fatty acid amide hydrolase 2.	0.659
ASNSD1	GATB	ENSLACP00000015491	ENSLACP00000004894	Asparagine synthetase domain containing 1.	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	0.963
ASNSD1	GMPS	ENSLACP00000015491	ENSLACP00000008506	Asparagine synthetase domain containing 1.	Guanine monophosphate synthase.	0.735
ASNSD1	QARS1	ENSLACP00000015491	ENSLACP00000006386	Asparagine synthetase domain containing 1.	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.417
ASNSD1	RPL39	ENSLACP00000015491	ENSLACP00000010071	Asparagine synthetase domain containing 1.	Ribosomal protein L39.	0.417
ASNSD1	TMEM109	ENSLACP00000015491	ENSLACP00000000235	Asparagine synthetase domain containing 1.	Uncharacterized protein.	0.962
ASNSD1	YARS1	ENSLACP00000015491	ENSLACP00000017686	Asparagine synthetase domain containing 1.	Tyrosine--tRNA ligase.	0.755
DARS2	ASNSD1	ENSLACP00000013454	ENSLACP00000015491	Aspartyl-tRNA synthetase 2, mitochondrial.	Asparagine synthetase domain containing 1.	0.609
DARS2	EARS2	ENSLACP00000013454	ENSLACP00000001045	Aspartyl-tRNA synthetase 2, mitochondrial.	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.868
DARS2	EPRS1	ENSLACP00000013454	ENSLACP00000013372	Aspartyl-tRNA synthetase 2, mitochondrial.	Glutamyl-prolyl-tRNA synthetase.	0.989
DARS2	FAAH2	ENSLACP00000013454	ENSLACP00000017097	Aspartyl-tRNA synthetase 2, mitochondrial.	Fatty acid amide hydrolase 2.	0.856
DARS2	GATB	ENSLACP00000013454	ENSLACP00000004894	Aspartyl-tRNA synthetase 2, mitochondrial.	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	0.997
DARS2	GMPS	ENSLACP00000013454	ENSLACP00000008506	Aspartyl-tRNA synthetase 2, mitochondrial.	Guanine monophosphate synthase.	0.945
DARS2	QARS1	ENSLACP00000013454	ENSLACP00000006386	Aspartyl-tRNA synthetase 2, mitochondrial.	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.781
DARS2	RPL39	ENSLACP00000013454	ENSLACP00000010071	Aspartyl-tRNA synthetase 2, mitochondrial.	Ribosomal protein L39.	0.745
DARS2	YARS1	ENSLACP00000013454	ENSLACP00000017686	Aspartyl-tRNA synthetase 2, mitochondrial.	Tyrosine--tRNA ligase.	0.936
EARS2	ASNSD1	ENSLACP00000001045	ENSLACP00000015491	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Asparagine synthetase domain containing 1.	0.572

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.782

expected number of edges:

11

PPI enrichment p-value:

0.000292

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

3 of 47

2.11

1.09

0.0090

GO:0006534

Cysteine metabolic process

2 of 8

2.71

1.03

0.0133

GO:0009064

Glutamine family amino acid metabolic process

3 of 65

1.97

1.01

0.0117

GO:0006750

Glutathione biosynthetic process

2 of 10

2.61

1.01

0.0146

GO:1901605

Alpha-amino acid metabolic process

4 of 170

1.68

1.0

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 44

2.14

1.28

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005814

Centriole

3 of 108

1.75

0.83

0.0239

GO:0005813

Centrosome

4 of 413

1.29

0.71

0.0239

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28614

Glutathione metabolism, and Oxidoreductase activity, acting on a sulfur group of donors

8 of 127

2.11

5.12

1.06e-12

CL:28680

Gamma-glutamyltranspeptidase, and Glutamate-cysteine ligase complex

3 of 7

2.94

2.75

9.75e-06

CL:28789

Mixed, incl. Metalloaminopeptidase activity, and Aspartate and asparagine metabolism

4 of 38

2.33

2.64

8.07e-06

CL:28620

Glutathione conjugation, and Glutathione peroxidase

4 of 39

2.32

2.63

8.07e-06

CL:28845

Negative regulation of cilium assembly, and Domain in ubiquitin-specific proteases.

3 of 10

2.79

2.57

1.94e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00480

Glutathione metabolism

5 of 126

1.91

2.78

5.66e-07

map00270

Cysteine and methionine metabolism

4 of 78

2.02

2.52

5.36e-06

map00250

Alanine, aspartate and glutamate metabolism

2 of 64

1.8

0.84

0.0229

map04216

Ferroptosis

2 of 74

1.74

0.82

0.0243

map01100

Metabolic pathways

9 of 3053

0.78

0.72

4.65e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174403

Glutathione synthesis and recycling

4 of 19

2.63

3.37

4.63e-07

MAP-156590

Glutathione conjugation

4 of 34

2.38

2.96

1.92e-06

MAP-156580

Phase II - Conjugation of compounds

4 of 95

1.93

2.02

6.44e-05

MAP-211859

Biological oxidations

4 of 254

1.51

1.17

0.0022

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 105

1.76

1.11

0.0058

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097721

Ciliary vesicle

2 of 4

3.01

1.32

0.0042

GOCC:0005814

Centriole

3 of 59

2.01

1.23

0.0042

GOCC:0005815

Microtubule organizing center

4 of 215

1.58

1.1

0.0042

GOCC:0005813

Centrosome

3 of 120

1.71

0.99

0.0098

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About