STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (270 aa)    
Predicted Functional Partners:
NOTUM
Notum, palmitoleoyl-protein carboxylesterase.
    
 0.735
EXT2
Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family.
     
 0.649
SULF2
Extracellular sulfatase.
    
 
 0.634
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1b.
     
 0.620
DCN
Decorin; May affect the rate of fibrils formation.
    
 0.615
EXT1
Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.
     
 0.607
SDC3
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.606
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.597
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.597
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.597
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.