PINK1 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PINK1

PTEN induced kinase 1. (467 aa)

Predicted Functional Partners:

MFN2

0.995

KXD1

0.986

RPS27A

0.973

MFN1

0.931

PARK7

0.889

OPA1

0.884

PARL

0.883

SNCA

0.881

LOC102350907

0.866

VPS35

0.847

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXD1	MFN1	ENSLACP00000009213	ENSLACP00000017343	Ubiquitin-like domain-containing protein.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.480
KXD1	MFN2	ENSLACP00000009213	ENSLACP00000005825	Ubiquitin-like domain-containing protein.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.480
KXD1	PARK7	ENSLACP00000009213	ENSLACP00000009483	Ubiquitin-like domain-containing protein.	Parkinsonism associated deglycase.	0.622
KXD1	PINK1	ENSLACP00000009213	ENSLACP00000020138	Ubiquitin-like domain-containing protein.	PTEN induced kinase 1.	0.986
KXD1	RPS27A	ENSLACP00000009213	ENSLACP00000008678	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.999
LOC102350907	MFN1	ENSLACP00000003879	ENSLACP00000017343	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.480
LOC102350907	MFN2	ENSLACP00000003879	ENSLACP00000005825	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.480
LOC102350907	PARK7	ENSLACP00000003879	ENSLACP00000009483	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Parkinsonism associated deglycase.	0.622
LOC102350907	PINK1	ENSLACP00000003879	ENSLACP00000020138	Ubiquitin A-52 residue ribosomal protein fusion product 1.	PTEN induced kinase 1.	0.866
LOC102350907	RPS27A	ENSLACP00000003879	ENSLACP00000008678	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ribosomal protein S27a.	0.994
MFN1	KXD1	ENSLACP00000017343	ENSLACP00000009213	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Ubiquitin-like domain-containing protein.	0.480
MFN1	LOC102350907	ENSLACP00000017343	ENSLACP00000003879	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.480
MFN1	MFN2	ENSLACP00000017343	ENSLACP00000005825	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.999
MFN1	OPA1	ENSLACP00000017343	ENSLACP00000003936	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.877
MFN1	PARL	ENSLACP00000017343	ENSLACP00000006783	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Presenilin associated, rhomboid-like a.	0.565
MFN1	PINK1	ENSLACP00000017343	ENSLACP00000020138	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	PTEN induced kinase 1.	0.931
MFN1	RPS27A	ENSLACP00000017343	ENSLACP00000008678	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Ribosomal protein S27a.	0.616
MFN2	KXD1	ENSLACP00000005825	ENSLACP00000009213	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Ubiquitin-like domain-containing protein.	0.480
MFN2	LOC102350907	ENSLACP00000005825	ENSLACP00000003879	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.480
MFN2	MFN1	ENSLACP00000005825	ENSLACP00000017343	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.999

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Network Stats

number of nodes:

5

number of edges:

9

average node degree:

3.6

avg. local clustering coefficient:

0.9

expected number of edges:

9

PPI enrichment p-value:

0.39

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

6 of 123

1.23

1.1

0.00069

GO:0071103

DNA conformation change

3 of 25

1.62

0.98

0.0092

GO:0090305

Nucleic acid phosphodiester bond hydrolysis

4 of 61

1.36

0.94

0.0061

GO:0090304

Nucleic acid metabolic process

7 of 271

0.95

0.77

0.0017

GO:0006139

Nucleobase-containing compound metabolic process

8 of 441

0.8

0.63

0.0018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

6 of 74

1.45

1.69

2.18e-05

GO:0140657

ATP-dependent activity

6 of 120

1.24

1.27

0.00011

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 175

1.14

1.19

5.10e-05

GO:0004527

Exonuclease activity

3 of 22

1.68

1.07

0.0063

GO:0008094

ATP-dependent activity, acting on DNA

3 of 23

1.66

1.06

0.0063

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030894

Replisome

2 of 6

2.06

0.85

0.0255

GO:1990391

DNA repair complex

2 of 7

2.0

0.84

0.0255

GO:0043590

Bacterial nucleoid

2 of 16

1.64

0.78

0.0274

GO:0032991

Protein-containing complex

5 of 222

0.89

0.53

0.0255

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:594

Mixed, incl. Homologous recombination, and DNA repair complex

9 of 42

1.87

4.51

2.98e-13

CL:664

Mixed, incl. 5-3 exonuclease, and Helicase and RNase D C-terminal

5 of 5

2.54

4.4

3.00e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168256

Immune System

3 of 36

1.46

1.08

0.0033

MAP-168249

Innate Immune System

2 of 30

1.37

0.66

0.0389

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0540

Nuclease

3 of 31

1.53

0.84

0.0177

KW-0347

Helicase

3 of 29

1.56

0.84

0.0177

KW-0269

Exonuclease

2 of 14

1.7

0.77

0.0311

KW-0235

DNA replication

2 of 16

1.64

0.76

0.0311

KW-0233

DNA recombination

2 of 15

1.67

0.76

0.0311

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036279

5-3 exonuclease, C-terminal domain superfamily

2 of 2

2.54

0.81

0.0345

IPR020046

5-3 exonuclease, alpha-helical arch, N-terminal

2 of 2

2.54

0.81

0.0345

IPR020045

DNA polymerase I-like, H3TH domain

2 of 2

2.54

0.81

0.0345

IPR008918

Helix-hairpin-helix motif, class 2

2 of 2

2.54

0.81

0.0345

IPR002421

5-3 exonuclease

2 of 2

2.54

0.81

0.0345

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00279

Helix-hairpin-helix class 2 (Pol1 family) motifs

2 of 2

2.54

1.24

0.0054

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