STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITCHE3 ubiquitin-protein ligase. (880 aa)    
Predicted Functional Partners:
WWP1
E3 ubiquitin-protein ligase.
  
 
0.983
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.970
RPS27A
Ribosomal protein S27a.
    
 0.956
MDM2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
    
 0.921
CBL
Cbl proto-oncogene.
    
 0.919
NEDD4L
E3 ubiquitin-protein ligase.
    
0.912
TXNIP
Thioredoxin interacting protein.
    
 
 0.911
RNF41
Ring finger protein 41.
    
 0.911
SMURF2
E3 ubiquitin-protein ligase.
     
0.901
UBE2L6
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.897
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.