STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1104 aa)    
Predicted Functional Partners:
NPC2
NPC intracellular cholesterol transporter 2.
   
 0.961
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.832
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.832
MYCN
MYCN proto-oncogene, bHLH transcription factor.
   
 0.795
ABCG5
ATP binding cassette subfamily G member 5.
   
 
 0.683
INSIG2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
   
 0.665
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 0.665
ABCG8
ATP binding cassette subfamily G member 8.
   
 
 0.647
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
  
 0.613
SCARF2
Scavenger receptor class F member 2.
      
 0.580
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.