STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (929 aa)    
Predicted Functional Partners:
EDEM1
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
    
0.930
EDEM2
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
    
0.927
SEL1L
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 
 0.637
TXNDC11
Thioredoxin domain containing 11.
    
 
 0.574
DNAJC3
DnaJ heat shock protein family (Hsp40) member C3.
    
 
 0.568
RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]
    
 
 0.504
SEL1L2
SEL1L2 adaptor subunit of ERAD E3 ligase.
   
 
 0.484
LOC102359772
DnaJ (Hsp40) homolog, subfamily C, member 3b.
    
 
 0.442
MLEC
Malectin.
      
 0.424
PGBD5
PiggyBac transposable element derived 5.
      
 0.420
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.