STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POLE3Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa)    
Predicted Functional Partners:
POLE
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 0.999
POLE4
DNA polymerase epsilon 4, accessory subunit.
    
 0.999
POLE2
DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.
    
 0.998
CHRAC1
Chromatin accessibility complex subunit 1.
    
 0.995
H3AL79_LATCH
DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
     
 0.975
PRIM1
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
     
 0.969
H2ZWI5_LATCH
Uncharacterized protein.
    
 0.967
BAZ1A
Bromodomain adjacent to zinc finger domain 1A.
    
 
 0.964
CDC45
Cell division cycle 45.
    
 0.962
MCM2
DNA helicase; Belongs to the MCM family.
   
 
 0.961
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.