itch protein (Lepisosteus oculatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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[Homology]

Score

itch

E3 ubiquitin-protein ligase. (908 aa)

Predicted Functional Partners:

rps27a

0.990

notch1

0.989

RNF11

0.989

cflar

0.982

W5LYQ5_LEPOC

0.977

spart

0.977

W5M0P7_LEPOC

0.975

txnip

0.975

cxcr4

0.971

tp53

0.952

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RNF11	W5LYQ5_LEPOC	ENSLOCP00000011493	ENSLOCP00000001262	Ring finger protein 11b.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.831
RNF11	itch	ENSLOCP00000011493	ENSLOCP00000001036	Ring finger protein 11b.	E3 ubiquitin-protein ligase.	0.989
RNF11	rps27a	ENSLOCP00000011493	ENSLOCP00000019146	Ring finger protein 11b.	Ribosomal protein S27a.	0.927
W5LYQ5_LEPOC	RNF11	ENSLOCP00000001262	ENSLOCP00000011493	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ring finger protein 11b.	0.831
W5LYQ5_LEPOC	itch	ENSLOCP00000001262	ENSLOCP00000001036	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	E3 ubiquitin-protein ligase.	0.977
W5LYQ5_LEPOC	notch1	ENSLOCP00000001262	ENSLOCP00000004070	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Notch receptor 1a.	0.471
W5LYQ5_LEPOC	rps27a	ENSLOCP00000001262	ENSLOCP00000019146	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ribosomal protein S27a.	0.998
W5LYQ5_LEPOC	tp53	ENSLOCP00000001262	ENSLOCP00000017063	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.605
W5M0P7_LEPOC	itch	ENSLOCP00000001954	ENSLOCP00000001036	Arrestin domain containing 1b.	E3 ubiquitin-protein ligase.	0.975
cflar	itch	ENSLOCP00000012056	ENSLOCP00000001036	CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family.	E3 ubiquitin-protein ligase.	0.982
cflar	rps27a	ENSLOCP00000012056	ENSLOCP00000019146	CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family.	Ribosomal protein S27a.	0.435
cflar	tp53	ENSLOCP00000012056	ENSLOCP00000017063	CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.867
cxcr4	itch	ENSLOCP00000001045	ENSLOCP00000001036	Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family.	E3 ubiquitin-protein ligase.	0.971
cxcr4	notch1	ENSLOCP00000001045	ENSLOCP00000004070	Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family.	Notch receptor 1a.	0.521
cxcr4	tp53	ENSLOCP00000001045	ENSLOCP00000017063	Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.508
itch	RNF11	ENSLOCP00000001036	ENSLOCP00000011493	E3 ubiquitin-protein ligase.	Ring finger protein 11b.	0.989
itch	W5LYQ5_LEPOC	ENSLOCP00000001036	ENSLOCP00000001262	E3 ubiquitin-protein ligase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.977
itch	W5M0P7_LEPOC	ENSLOCP00000001036	ENSLOCP00000001954	E3 ubiquitin-protein ligase.	Arrestin domain containing 1b.	0.975
itch	cflar	ENSLOCP00000001036	ENSLOCP00000012056	E3 ubiquitin-protein ligase.	CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family.	0.982
itch	cxcr4	ENSLOCP00000001036	ENSLOCP00000001045	E3 ubiquitin-protein ligase.	Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family.	0.971