Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pplPeriplakin. (1758 aa)    
Predicted Functional Partners:
W5LWS8_LEPOC
Kazrin, periplakin interacting protein a.
    
 0.818
evpl
Envoplakin a.
   
 
 0.744
mpl
MPL proto-oncogene, thrombopoietin receptor.
      
 0.701
pkp1
Plakophilin 1b.
    
 0.697
W5NDN5_LEPOC
Uncharacterized protein.
    
 0.697
LOC102688988
Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
   
 0.681
sptan1
Spectrin alpha, non-erythrocytic 1.
   
 0.661
LOC102695806
Junction plakoglobin b.
   
 0.656
W5NNI1_LEPOC
Extracellular leucine-rich repeat and fibronectin type III domain containing 1b.
    
 0.640
eny2
Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]
    
 0.605
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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